1 paper5 findings
Telomere length
upin humans1downin humans1OR 2.26
Telomere length is associated with early pregnancy loss in humans (OR 2.26, interval 1.26–4.04).
“low methylation highest odds than that of short telomeres (OR = 4.44, 2.45-8.03; P < 0.0001 and OR = 2.26, 1.26-4.04; P = 0.005, respectively)”
HumansShort telomeres in pregnant womenfemales
LINE-1 Methylation sustains telomere length in pregnant women: effects on pregnancy failure
Clinical epigeneticsJul 23, 2025
Early pregnancy loss is associated with telomere length in humans (T/S: 322.6 ± 142.0 versus 455.0 ± 290.6).
“EPL group having lower values (T/S: 322.6 ± 142.0 versus 455.0 ± 290.6; P < 0.000001”
HumansEarly pregnancy loss compared with voluntary interruption of pregnancyfemalesn = 242
LINE-1 Methylation sustains telomere length in pregnant women: effects on pregnancy failure
Clinical epigeneticsJul 23, 2025
LINE-1 methylation
upin humans1downin humans1OR 4.44
LINE-1 methylation is associated with early pregnancy loss in humans (OR 4.44, interval 2.45–8.03).
“low methylation highest odds than that of short telomeres (OR = 4.44, 2.45-8.03; P < 0.0001 and OR = 2.26, 1.26-4.04; P = 0.005, respectively)”
HumansLow LINE-1 methylation in pregnant womenfemales
LINE-1 Methylation sustains telomere length in pregnant women: effects on pregnancy failure
Clinical epigeneticsJul 23, 2025
Early pregnancy loss is associated with LINE-1 methylation in humans (81.66 ± 4.2% versus 86.01 ± 3.7%).
“EPL group having lower values (T/S: 322.6 ± 142.0 versus 455.0 ± 290.6; P < 0.000001 and LINE-1 %: 81.66 ± 4.2 versus 86.01 ± 3.7; P < 0.000001)”
HumansEarly pregnancy loss compared with voluntary interruption of pregnancyfemalesn = 242
LINE-1 Methylation sustains telomere length in pregnant women: effects on pregnancy failure
Clinical epigeneticsJul 23, 2025
Jointly low telomere length and LINE-1 methylation
upin humans1OR 9.7
Jointly low telomere length and LINE-1 methylation is associated with early pregnancy loss in humans (OR 9.70, interval 3.94–23.72).
“significant risk of early pregnancy failure when women carried both risk conditions, low TL and LINE-1 methylation (OR = 9.70, 3.94-23.72; P < 0.0001)”
HumansBoth measures below the 25th percentile compared with both above the 75th percentilefemalesn = 242
LINE-1 Methylation sustains telomere length in pregnant women: effects on pregnancy failure
Clinical epigeneticsJul 23, 2025
1 trialPhase 219 people
1 trial32 people
The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic signaling in aging…The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic signaling in aging female mice.