Early age-related macular degeneration
4 papers8 findings
- Humans4
Effects
2Mortality
no changein humans1
1 study
Mortality
no changein humans1
Early age-related macular degeneration has no effect on mortality in humans.
“In the full cohort (n = 12 536), early AMD was not significantly associated with all-cause mortality.”
HumansEarly age-related macular degeneration at baseline10 yearsn = 12,536
Ophthalmology1 Jan 2007
Incident coronary heart disease
no changein humans1
1 study
Incident coronary heart disease
no changein humans1
Early age-related macular degeneration has no effect on incident coronary heart disease in humans (Relative risk 1.08, 95% CI 0.82-1.42).
“early AMD was not associated with incident CHD (relative risk, 1.08; 95% confidence interval, 0.82-1.42).”
HumansEarly age-related macular degeneration at baseline; adjusted analysis10 yearsn = 11,414
Ophthalmology1 Jan 2007
Upstream
1Waist-hip ratio
no changein humans1
1 study
Waist-hip ratio
no changein humans1
Waist-hip ratio has no effect on early age-related macular degeneration in humans.
“Smoking status modified the relation between waist/hip ratio and early AMD (P = 0.05), with no association for former smokers.”
HumansFormer smokersmales
Abdominal obesity and age-related macular degeneration
American journal of epidemiology21 Mar 2011
Associations
5Adiposity
downin humans1OR 0.89–0.93
1 study
Adiposity
downin humans1OR 0.89–0.93
Adiposity is associated with early age-related macular degeneration in humans (ORs 0.89–0.93 across adiposity measures).
“For women, there were inverse associations with early AMD for all adiposity measures (odds ratios = 0.89-0.93; P = 0.002-0.02)”
Humansfemales
Abdominal obesity and age-related macular degeneration
American journal of epidemiology21 Mar 2011
Waist-hip ratio
upin humans1OR 1.13
1 study
Waist-hip ratio
upin humans1OR 1.13
Waist-hip ratio is associated with early age-related macular degeneration in humans (OR 1.13, 95% CI 1.01–1.26 per 0.1 increase).
“was associated with a 13% increase in the odds of early AMD (odds ratio = 1.13, 95% confidence interval: 1.01, 1.26; P = 0.03)”
HumansEach 0.1 increase in waist/hip ratiomales
Abdominal obesity and age-related macular degeneration
American journal of epidemiology21 Mar 2011
Echolucent carotid artery plaque
downin humans1OR 0.37
1 study
Echolucent carotid artery plaque
downin humans1OR 0.37
Echolucent carotid artery plaque is associated with early age-related macular degeneration in humans (OR 0.37, 95% CI 0.18-0.74).
“the presence of echolucent carotid artery plaque (odds ratio for present vs no plaque, 0.37; 95% confidence interval, 0.18-0.74) in the whole cohort”
Humanspresent vs no plaquen = 6,176
Archives of ophthalmology (Chicago, Ill. : 1960)1 Apr 2007
High-density lipoprotein cholesterol
upin humans1OR 1.16
1 study
High-density lipoprotein cholesterol
upin humans1OR 1.16
High-density lipoprotein cholesterol is associated with early age-related macular degeneration in humans (OR 1.16, 95% CI 1.01-1.36).
“early AMD was associated with a higher serum high-density lipoprotein cholesterol level (odds ratio per 15 mg/dL, 1.16; 95% confidence interval, 1.01-1.36)”
Humansper 15 mg/dLn = 6,176
Archives of ophthalmology (Chicago, Ill. : 1960)1 Apr 2007
White blood cell count
upin humans1RR 1.85
1 study
White blood cell count
upin humans1RR 1.85
White blood cell count raises the risk of early age-related macular degeneration in humans (RR 1.85 (95% CI: 1.33, 2.58)).
“The multivariable relative risk comparing tertile 3 of WBC count (>6.7 x 10(9) cells/liter) with tertile 1 (</=5.5 x 10(9) cells/liter) was 1.85 (95% confidence interval: 1.33, 2.58).”
Humans10-yearn = 3,654
American journal of epidemiology16 Nov 2006
Funding
1 grant since 2023National Eye InstituteUS$2m