Diffuse cutaneous systemic sclerosis

2 papers1 finding

Human trial1
Humans1

Effects

1

DNA damage response

upin human cells1

1 study

Diffuse cutaneous systemic sclerosis increases DNA damage response in human cells.
“dcSSc fibroblasts demonstrated increased pH2AX DNA double-strand-break foci yet remained apoptosis resistant.”
Cellsin dcSSc fibroblastsdermal fibroblasts
A PERK-FOXO1 AXIS LINKS DNA DAMAGE TO FIBROBLAST SURVIVAL IN DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS
bioRxiv (Cold Spring Harbor Laboratory)18 Feb 2026Preprint

More on DNA damage response

Trial sponsors

Miltenyi Biomedicine
Company1 trialPhase 148 people
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
1 trialPhase 324 people
Second Affiliated Hospital, Zhejiang University, School of Medicine
1 trialPhase 238 people
Boston University
1 trialPhase 130 people
David Porter
1 trialPhase 124 people

Latest

1 in 12 months

bioRxiv18 Feb

A PERK-FOXO1 AXIS LINKS DNA DAMAGE TO FIBROBLAST SURVIVAL IN DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS

Preprint: study in peopleDNA damage response

Rheumatology15 Dec

Dermal cellular senescence and EndMT in patients with systemic sclerosis undergoing cyclophosphamide or aHSCT treatment

Randomised trial in 14 peopleInterventions