Dementia status

2-step shared parameter model predicts dementia status in silico (91.3% accuracy, 98.5% specificity, 43.8% sensitivity).

“In the validation sample, relative to the CHS Cognition Study dementia classifications used as the "reference standard," specificity (98.5%), positive predictive value (81.9%), negative predictive value (92.0%), and accuracy (91.3%) were high”

In silicoin validation sample relative to reference standardn = 1,334

Development and validation of a 2-step shared parameter model for dementia imputation in the Cardiovascular Health Study cohort

The journals of gerontology. Series A, Biological sciences and medical sciences·14 Mar 2026