COPD-OSA overlap syndrome

1. COPD-OSA overlap syndrome has no effect on cardiovascular mortality in humans.

   “Cardiovascular mortality was significantly higher in patients with COPD-OSA overlap compared with OSA alone (adjusted hazard ratio 1.72 (1.58-1.88); p<0.001) but not compared with COPD alone.”

   HumansCompared with COPD alone

   Chronic lung disease plus sleep apnea linked to higher heart risk

   ERJ open research·Oct 26, 2026

1. COPD-OSA overlap syndrome is associated with heart failure in humans (69% higher risk versus COPD; 101% higher risk versus OSA).

   “and 69% and 101% increased risk of developing heart failure compared with COPD and OSA respectively.”

   HumansCompared with COPD alone and obstructive sleep apnea alone

   Chronic lung disease plus sleep apnea linked to higher heart risk

   ERJ open research·Oct 26, 2026

More on Heart failure

1. COPD-OSA overlap syndrome is associated with acute coronary syndrome in humans (27% higher risk versus COPD alone; 58% higher risk versus OSA alone).

   “People with COPD-OSA overlap had 27% and 58% increased risk of developing ACS compared with COPD and OSA alone respectively”

   HumansCompared with COPD alone and obstructive sleep apnea alone

   Chronic lung disease plus sleep apnea linked to higher heart risk

   ERJ open research·Oct 26, 2026

More on Acute coronary syndrome

1. COPD-OSA overlap syndrome is associated with cardiovascular mortality in humans (Adjusted HR 1.72 (1.58–1.88); p<0.001).

   “Cardiovascular mortality was significantly higher in patients with COPD-OSA overlap compared with OSA alone”

   HumansCompared with obstructive sleep apnea alone

   Chronic lung disease plus sleep apnea linked to higher heart risk

   ERJ open research·Oct 26, 2026