Advanced CKM syndrome is linked to suicidal death

In a nationwide study of 4,601,001 Korean adults, researchers evaluated how the Cardiovascular-Kidney-Metabolic (CKM) syndrome framework relates to suicide-related mortality. Using the Korean National Health Insurance Service database, the team categorized participants into CKM stages 0 through 4 and followed them over a median of 10.11 years, during which 12,034 suicidal deaths occurred. After adjusting for clinicodemographic factors, comorbidities, and psychiatric diagnoses, advanced CKM stages were associated with a higher risk of suicidal death, showing an adjusted hazard ratio of 1.328 for stage 3 and 1.319 for stage 4. When accounting for non-suicide death as a competing risk, the subdistribution hazard ratios remained significant at 1.199 for stage 3 and 1.246 for stage 4. Exploratory subgroup analyses indicated the link was strongest in adults aged 20 to 39 and among individuals without a claims-based depression diagnosis.