Cardio-renal-metabolic comorbidity progression

1 paper1 finding

Humans1

Upstream

1

GDF-15

mediatesin humans1

1 study

GDF-15 mediates cardio-renal-metabolic comorbidity progression in humans (13.10-43.23% mediated proportion).
“Mediation analyses identified nine circulating key proteins that statistically mediated the associations between biological aging and CKM progression, with GDF15, ADM, and HAVCR1 showing the largest mediated proportion”
Humansn = 35,118
Proteomics mediates the effects of biological aging on the progression of cardio-renal-metabolic comorbidity: a UK biobank cohort study
Cardiovascular diabetology9 Dec 2025

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Cardiovascular Diabetology10 Dec

Proteomics mediates the effects of biological aging on the progression of cardio-renal-metabolic comorbidity: a UK biobank cohort study

Cohort study of 330,177 peopleBiomarkers