Autoimmune arthritis

1. PERP protects against autoimmune arthritis in mice.

   “middle-aged floxed mice exhibited excessive accumulation of activated CD4+ T-cells in peripheral blood, alongside T cell-mediated autoimmune arthritis.”

   Animalsconditional knockout of Perp

   Perp Deficiency Induces Defective Negative Selection and Autoimmune Arthritis in Aged Mice

   Aging cell·23 Apr 2026

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