Aortic stenosis progression

1. SGLT2 inhibitors lower the risk of aortic stenosis progression in humans (matched HR 0.589 [95% CI: 0.39–0.90]).

   “The SGLT2i group was less likely to progress to severe AS (matched HR 0.589 [95% CI: 0.39–0.90]; p=0.013).”

   Humanspropensity-matched cohort with moderate aortic stenosisup to 3 yearsn = 620

   Sodium-Glucose Cotransporter-2 Inhibitors in Moderate Aortic Stenosis

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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