Acute exacerbation

There are 3 papers on acute exacerbation in aging research: 2 observational studies in people, 1 review. The newest story, Oct 31, 2026: “Frailty and lung measures help assess risk in lung-scarring disease”.

Disease

3 papers study it87 more mention it3 findings

8 new papers in 30 daysSee all 90

“acute exacerbations occurred more frequently in the low ESMI group and low PMI group, particularly among non-IPF patients.”
Prognostic impact of muscle mass in idiopathic interstitial pneumonia: analysis of idiopathic pulmonary fibrosis and other idiopathic interstitial pneumoniasBMC pulmonary medicine2025doi:10.1186/s12890-025-03942-0
  • Humans2

Associations

3

Low pectoralis muscle index

upin humans1

1 study
  1. Low pectoralis muscle index is associated with acute exacerbation in humans (particularly among non-IPF patients).

    “acute exacerbations occurred more frequently in the low ESMI group and low PMI group, particularly among non-IPF patients.”

    Humansparticularly among non-IPF patientsskeletal muscle

    Prognostic impact of muscle mass in idiopathic interstitial pneumonia: analysis of idiopathic pulmonary fibrosis and other idiopathic interstitial pneumonias

    BMC pulmonary medicine

More on Low pectoralis muscle index

Low erector spinae muscle index

upin humans1

1 study
  1. Low erector spinae muscle index is associated with acute exacerbation in humans (particularly among non-IPF patients).

    “acute exacerbations occurred more frequently in the low ESMI group and low PMI group, particularly among non-IPF patients.”

    Humansparticularly among non-IPF patientsskeletal muscle

    Prognostic impact of muscle mass in idiopathic interstitial pneumonia: analysis of idiopathic pulmonary fibrosis and other idiopathic interstitial pneumonias

    BMC pulmonary medicine

More on Low erector spinae muscle index

Frailty

upin humans1OR 2.2

1 study
  1. Frailty predicts acute exacerbation in patients with stable COPD (OR 2.20, 95% CI 1.26-3.81).

    “In addition, frailty significantly predicted all acute exacerbation (OR 2.20, 95% CI 1.26-3.81) but not moderate to severe acute exacerbation (OR 1.42, 95% CI 0.94-2.17) in patients with stable COPD.”

    Reviewin patients with stable COPD

    Association of Prefrailty and Frailty With All-Cause Mortality, Acute Exacerbation, and Hospitalization in Patients With Chronic Obstructive Pulmonary Disease: A Meta-Analysis

    Journal of the American Medical Directors Association

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Archivos de Bronconeumologia

Frailty and lung measures help assess risk in lung-scarring disease

Frailty was associated with higher risk of death or sudden worsening compared with being below the frailty threshold (hazard ratio 3.94).Frailty was associated with higher risk of death or sudden worsening compared with being below the frailty threshold (hazard ratio 3.94).

Cohort · 140 peopleBiomarkers
Journal of Global Health

Social limits linked to death in chronic obstructive pulmonary disease

Patients with restricted social activity had a higher relative rate of death over four years than those without restrictions, with a hazard ratio of 1.752.Patients with restricted social activity had a higher relative rate of death over four years than those without restrictions, with a hazard ratio of 1.752.

Aging Cell

Senescent human lung cells show altered virus defenses

Experiments with influenza A found higher virus levels in senescent lung cells, with a distinct antiviral response in cells from people with idiopathic pulmonary…Experiments with influenza A found higher virus levels in senescent lung cells, with a distinct antiviral response in cells from people with idiopathic pulmonary fibrosis.

Human cell studyCellular senescence

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