Acute allograft rejection

Recipient age is associated with acute allograft rejection in humans (Adjusted OR 0.83 (95% CI 0.71–0.98) per one standard deviation increase in recipient age).

“each one standard deviation increase in recipient age was associated with a ∼17% lower odds of allograft rejection (adjusted OR 0.83, 95% CI 0.71-0.98).”

HumansHeart transplant recipients receiving immunosuppressionheartn = 799

Aging under immunosuppression reshapes human immune compartments and lowers clinical alloreactivity after heart transplantation

bioRxiv (Cold Spring Harbor Laboratory)·26 Feb 2026Preprint