Immunosenescence and chronic low-grade inflammation pathway enrichment

Recipient age is associated with immunosenescence and chronic low-grade inflammation pathway enrichment in humans.

“genes upregulated with increasing recipient age were associated with enrichment for pathways involved in immunosenescence and chronic low-grade inflammation”

HumansGenes upregulated with recipient age in heart transplant recipientscirculating immune cellsn = 40

Aging under immunosuppression reshapes human immune compartments and lowers clinical alloreactivity after heart transplantation

bioRxiv (Cold Spring Harbor Laboratory)·26 Feb 2026Preprint