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Acral melanoma

There are 2 papers on acral melanoma in aging research: 2 observational studies in people. The newest story, Oct 15, 2026: “Melanoma risk linked to immune and cancer-related genes”.

Disease

2 papers study it1 more mentions it5 findings

1 new paper in 30 daysSee all 3 papers on acral melanoma

“AOE was significantly associated with higher odds of AM vs CM (AOR, 1.31; 95% CI, 1.06-1.62)”
Identification of Risk Factors for Acral Melanoma in US VeteransJAMA dermatology2026doi:10.1001/jamadermatol.2025.5827
  • Humans2

Associations

5

Nevus

upin humans1

1 study

  1. Nevus is associated with acral melanoma in humans (US veterans; compared with controls without melanoma).

    “Prior nevus was associated with higher odds of AM vs controls without melanoma.”

    HumansUS veterans; compared with controls without melanoma

    Identification of Risk Factors for Acral Melanoma in US Veterans

    JAMA dermatology

More on Nevus

Actinic keratosis

mixedin humans1

1 study

  1. Actinic keratosis is associated with acral melanoma in humans.

    “Prior KC and AK were associated with higher odds vs controls without melanoma but lower odds vs CM.”

    HumansUS veterans; higher odds versus controls without melanoma, lower odds versus nonacral cutaneous melanoma controls

    Identification of Risk Factors for Acral Melanoma in US Veterans

    JAMA dermatology

More on Actinic keratosis

Keratinocyte cancer

mixedin humans1

1 study

  1. Keratinocyte cancer is associated with acral melanoma in humans.

    “Prior KC and AK were associated with higher odds vs controls without melanoma but lower odds vs CM.”

    HumansUS veterans; higher odds versus controls without melanoma, lower odds versus nonacral cutaneous melanoma controls

    Identification of Risk Factors for Acral Melanoma in US Veterans

    JAMA dermatology

More on Keratinocyte cancer

Smoking

downin humans1

1 study

  1. Smoking is associated with acral melanoma in humans (US veterans; current smoking; compared with nonacral cutaneous melanoma controls) (AOR 0.65 (95% CI 0.52-0.81) vs CM; AOR 0.50 (95% CI 0.40-0.62) vs controls without melanoma).

    “Current smoking was associated with lower odds of AM (vs CM: AOR, 0.65; 95% CI, 0.52-0.81;”

    HumansUS veterans; current smoking; compared with nonacral cutaneous melanoma controls

    Identification of Risk Factors for Acral Melanoma in US Veterans

    JAMA dermatology

More on Smoking

Agent orange exposure

upin humans1

1 study

  1. Agent orange exposure is associated with acral melanoma in humans (US veterans; compared with nonacral cutaneous melanoma controls) (AOR 1.31 (95% CI 1.06-1.62) vs CM; AOR 1.27 (95% CI 1.04-1.56) vs controls without melanoma).

    “AOE was significantly associated with higher odds of AM vs CM (AOR, 1.31; 95% CI, 1.06-1.62)”

    HumansUS veterans; compared with nonacral cutaneous melanoma controls

    Identification of Risk Factors for Acral Melanoma in US Veterans

    JAMA dermatology

More on Agent orange exposure

Trial sponsors

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 1Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 02 papers in 12 months
medRxiv

Melanoma risk linked to immune and cancer-related genes

An analysis of 69,871 melanoma cases and 1,616,233 comparison participants identified 156 independent genetic signals in 116 regions linked to risk.An analysis of 69,871 melanoma cases and 1,616,233 comparison participants identified 156 independent genetic signals in 116 regions linked to risk.

Preprint: meta-analysisCutaneous melanoma
Paper

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