WID-HPV

1. WID-HPV is associated with epigenetic replicative age in humans (ρ = -0.43; P < .001).

   “negatively associated with epigenetic replicative age (ρ = -0.43; P < .001)”

   Humanscervix

   HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

   International journal of cancer·8 Mar 2023

More on Epigenetic replicative age

1. WID-HPV is associated with apoptosis in humans (ρ = 0.48; P < .001).

   “WID-HPV is positively associated with apoptosis (ρ = 0.48; P < .001)”

   Humanscervix

   HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

   International journal of cancer·8 Mar 2023

More on Apoptosis

1. Cervical intraepithelial neoplasia grade 1/2 is associated with WID-HPV in humans.

   “HPV-infected women with minor cytological alterations (cervical intraepithelial neoplasia grade 1/2, CIN1/2), but surprisingly not those with precancerous changes or invasive cervical cancer (CIN3+), show an increased WID-HPV index”

   Humansin HPV-infected womencervix

   HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

   International journal of cancer·8 Mar 2023

More on Cervical intraepithelial neoplasia grade 1/2

1. WID-HPV predicts human papillomavirus infection in humans (AUC = 0.78, 95% CI: 0.72-0.85).

   “a signature reflective of changes in the healthy host epigenome related to high-risk HPV strains (AUC = 0.78, 95% CI: 0.72-0.85, in nondiseased women)”

   Humansin nondiseased womencervix

   HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

   International journal of cancer·8 Mar 2023

More on Human papillomavirus infection