3 papers2 findings
Nuts
upin humans1
Nuts increase urolithin A in humans.
“Ellagitannin-derived urolithins A and B significantly increased after the nut-enriched-diet”
Human trialmetabolic syndrome12 weeks
Journal of agricultural and food chemistry5 Jun 2012
Cortical thickness
upin humans1
Urolithin A is associated with cortical thickness in humans (β = 0.023 [95% CI, 0.003-0.043] per 1-SD).
“greater increases in urolithin A (β = 0.023 [95% CI, 0.003-0.043] per 1-SD)”
HumansCognitively healthy participants allocated to the walnut diet; association with changes in urinary urolithin A.cerebral cortex2 yearsn = 55
Gut metabolites linked to preserved brain thickness in older adults
Food & function7 Oct 2026
National Institute of Diabetes and Digestive and Kidney DiseasesUS$956.5kNational Institute on AgingUS$1.3mNational Cancer InstituteUS$1m
Mechanisms underlying reversal of cardiac aging by urolithin a treatment
National Institute on AgingUniversity of WashingtonUS$634.7k2024–2026
Urolithin A nanoparticle therapy for acute kidney injury
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of Alabama in TuscaloosaUS$323.2k2021–2027
Colorectal Cancer (CRC) Prevention by Urolithin A in Rodent CRC models
National Cancer InstituteResearch Inst of Fox Chase Can CtrUS$1m2023–2026
In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.