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Urinary albumin excretion rate

Biomarker

3 papers3 findings

  • Human trial1
  • Humans2

Interventions

1

Rapamycin

upin humans1

1 study

  1. Rapamycin increases urinary albumin excretion rate in humans.

    “however, the urinary albumin excretion rate was higher in the sirolimus group.”

    Human trialautosomal dominant polycystic kidney diseasekidneytarget dose, 2 mg daily18 monthsn = 100

    Sirolimus and kidney growth in autosomal dominant polycystic kidney disease

    The New England journal of medicine26 Jun 2010

More on Rapamycin

Effects

1

Heart failure incidence

no changein humans1

1 study

  1. Urinary albumin excretion rate has no effect on heart failure incidence in humans.

    “There were no significant associations between UAER and HF incidence in individuals with anti-hypertensive treatment.”

    HumansReceiving anti-hypertensive treatmentMedian follow-up of 9.0 yearsmales

    Low-grade albuminuria and the incidence of heart failure in a community-based cohort of elderly men

    European heart journal11 May 2007

Associations

1

Heart failure incidence

upin humans1HR 1.49

1 study

  1. Urinary albumin excretion rate predicts heart failure incidence in humans (HR 1.49 per 1 SD increase in log UAER; 95% CI 1.13–1.98).

    “a 1 SD increase in log UAER increased the risk of HF in individuals without anti-hypertensive treatment (hazard ratio 1.49; 95% CI 1.13-1.98; P = 0.005).”

    HumansWithout anti-hypertensive treatment; adjusted for established and novel heart failure risk factorsMedian follow-up of 9.0 yearsmales

    Low-grade albuminuria and the incidence of heart failure in a community-based cohort of elderly men

    European heart journal11 May 2007

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