Ultra-conserved CpGs

1. Ultra-conserved CpGs is associated with developmental and ageing-related gene families in silico.

   “enrichment in four-fold degenerate sites, as well as within developmental and ageing-related gene families (AP-2, HOX-L, C2H2-ZNF, etc )”

   In silico

   Conserved Human CpG Dinucleotides Identify Enriched Ageing-related Signals in Developmental Pathways and the Brain

   bioRxiv (Cold Spring Harbor Laboratory)·20 Feb 2026Preprint

1. Ultra-conserved CpGs is associated with age-related differentially methylated regions in silico.

   “ucCpGs also strongly co-located within ageing-related Differentially Methylated Regions (age-DMRs), highlighting Clustered Protocadherin Gamma, as well as HSPA2 and LHFPL4 genes.”

   In silico

   Conserved Human CpG Dinucleotides Identify Enriched Ageing-related Signals in Developmental Pathways and the Brain

   bioRxiv (Cold Spring Harbor Laboratory)·20 Feb 2026Preprint

More on Age-related differentially methylated regions

1. Ultra-conserved CpGs is associated with brain-expressed genes in silico.

   “Extreme ucCpG clusters (≥16 ucCpGs/kb) were enriched for brain-expressed genes, as well as developmental and ageing/mortality pathways.”

   In silicoExtreme clusters containing ≥16 ucCpGs/kbbrain

   Conserved Human CpG Dinucleotides Identify Enriched Ageing-related Signals in Developmental Pathways and the Brain

   bioRxiv (Cold Spring Harbor Laboratory)·20 Feb 2026Preprint