TWEAK

3 papers1 finding

Human trial3

Associations

1

Sarcopenia

upin humans1

1 study

TWEAK raises the risk of sarcopenia in humans (13.4-fold).
“After adjustment for confounding variables, high levels of TWEAK were still associated with a 13.4-fold increased risk of sarcopenia.”
Humansafter adjustment for confounding variables
Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention
Journal of cachexia, sarcopenia and muscle10 Apr 2019

More on Sarcopenia

Funding

1 grant since 2025

National Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$535.1k

TWEAK/Fn14/UPR Signaling in Skeletal Muscle Wasting
National Institute of Arthritis and Musculoskeletal and Skin DiseasesUniversity of HoustonUS$535.1k2023–2028

Latest

2 in 12 months

Scientific Reports10 Sep

Targeting TWEAK to enhance mitochondrial biogenesis and attenuate age-related muscle mass loss

Experiments in miceMuscle

Experimental Gerontology25 Aug

Increased TWEAK and decreased MyoG expression in age-related impairment of muscle regeneration and H₂O₂-induced senescence-associated changes in C2C12 cells

Experiments in miceCellular senescence

The Journal of Nutrition, Health & Aging1 Jan

Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Older Adults with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Study

Randomised trial in peopleBeta-hydroxy-beta-methylbutyrate

Clinical Nutrition18 May

Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight

Non-randomised trial in peopleBariatric surgery

Journal of Cachexia, Sarcopenia and Muscle10 Apr

Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

Non-randomised trial in peopleLifestyle intervention