Total oocyte number

Age is associated with total oocyte number in mice.

“We find that newly activated oocytes represent a fixed fraction of the ovarian reserve, despite an age-related decline in total oocyte numbers.”

Animalsovaryfemales

3D Mapping of Intact Ovaries Reveals the Aging Dynamics of the Ovarian Reserve

bioRxiv (Cold Spring Harbor Laboratory)·8 Nov 2025Preprint