Fraction of newly activated oocytes in the ovarian reserve

Age has no effect on fraction of newly activated oocytes in the ovarian reserve in mice.

“We find that newly activated oocytes represent a fixed fraction of the ovarian reserve, despite an age-related decline in total oocyte numbers.”

Animalsovaryfemales

3D Mapping of Intact Ovaries Reveals the Aging Dynamics of the Ovarian Reserve

bioRxiv (Cold Spring Harbor Laboratory)·8 Nov 2025Preprint