Tightness of the high-convexity sulci plus enlargement of the Sylvian fissures

Biomarker

1 paper1 finding

Humans1

Associations

Cognitive decline

upin humans1OR 1.83

1 study

Tightness of the high-convexity sulci plus enlargement of the Sylvian fissures are associated with cognitive decline in humans (OR 1.83, 95% CI 1.16–2.87).
“THC plus ESF was associated with decline only in the combined cohort (OR, 1.83 [95% CI: 1.16, 2.87]; Holm-adjusted P = .04).”
HumansCombined cohort with normal cognition or mild cognitive impairment at baselinebrain5–7 years
Brain scan feature linked to later decline in thinking
Radiology1 Oct 2026

Latest

1 in 12 months

Radiology3 h

Brain scan feature linked to later decline in thinking

Among older adults with normal thinking abilities, narrow grooves near the brain’s top were linked to 2.95 times the odds of later decline versus no narrowing.Among older adults with normal thinking abilities, narrow grooves near the brain’s top were linked to 2.95 times the odds of later decline versus no narrowing.

Cohort study of 2,133 peopleBiomarkers

Paper

Tightness of the high-convexity sulci plus enlargement of the Sylvian fissures

Associations

Latest

Brain scan feature linked to later decline in thinking

Related