Thiol oxidation of proteins involved in proteostasis

Chronological ageing is associated with thiol oxidation of proteins involved in proteostasis in yeast cells.

“Our data determine early oxidation targets in key biological processes governing the de novo production of proteins, folding, and protein degradation.”

Cellswild-type

Analysis of ageing-dependent thiol oxidation reveals early oxidation of proteins involved in core proteostasis functions

bioRxiv (Cold Spring Harbor Laboratory)·8 May 2023Preprint