Telomere length shortening

1. Telomere length shortening predicts sarcopenia in humans (RRR = 1.55; 95% CI: 1.06-2.25).

   “and prospectively with a higher incidence (RRR = 1.55; 95% CI: 1.06-2.25) and persistence (RRR = 1.50; 95% CI: 1.01-2.24) of sarcopenia”

   Humanssalivan = 1,437

   Telomere Length is Associated with the Prevalence, Persistence, and Incidence of Sarcopenia

   Archives of medical research·May 27, 2024

2. Telomere length shortening is associated with sarcopenia in humans (OR = 1.31; 95% CI: 1.03-1.67).

   “a one standard deviation decrease in TL was cross-sectionally associated with higher odds of sarcopenia (OR = 1.31; 95% CI: 1.03-1.67)”

   Humanssalivan = 1,738

   Telomere Length is Associated with the Prevalence, Persistence, and Incidence of Sarcopenia

   Archives of medical research·May 27, 2024

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1. Telomere length shortening is associated with mortality in humans.

   “Shortened telomeres are present in SSc patients with interstitial lung disease (SSc-ILD) and associate with disease severity and mortality.”

   Reviewin SSc-ILD

   Molecular underpinnings of aging contributing to systemic sclerosis pathogenesis

   Current opinion in rheumatology·Oct 17, 2024

1. TERT-CLPTM1LVARIANTS is associated with telomere length shortening in humans (TL decline interaction P = 0.012 for rs401681 and 0.035 for rs465498).

   “the rs401681 and rs465498 could modify the effect of 1-OHP on increasing TL decline”

   HumansModification of the PAH exposure association; pronounced in rs401681TT and rs465498CC carriersleukocyte4 yearsn = 1,243

   The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT- CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort study

   Environmental pollution (Barking, Essex : 1987)·Aug 7, 2018

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