Tau PET uptake

1. VEGF is associated with tau PET uptake in humans (adjusted for age, sex, and cognitive group) (standardized β= 0.27, 95%CI[‐0.45,‐0.08], p = .005).

   “lower hVEGF levels (standardized β= 0.27, 95%CI[‐0.45,‐0.08], p = .005)”

   Humansadjusted for age, sex, and cognitive groupplasman = 122

   Correlation Between Plasma Biomarkers Identified in Normal, SCD, and MCI subjects, with PET Amyloid and Tau Neuroimaging

   AAIC 2025 abstract·Jan 9, 2026

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1. Glial fibrillary acidic protein is associated with tau PET uptake in humans (adjusted for age, sex, and cognitive group) (standardized β=0.20, 95%CI[0.04,0.36], p = .015).

   “higher GFAP levels (standardized β=0.20, 95%CI[0.04,0.36], p = .015)”

   Humansadjusted for age, sex, and cognitive groupplasman = 122

   Correlation Between Plasma Biomarkers Identified in Normal, SCD, and MCI subjects, with PET Amyloid and Tau Neuroimaging

   AAIC 2025 abstract·Jan 9, 2026

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1. Amyloid-beta 42 is associated with tau PET uptake in humans (adjusted for age, sex, and cognitive group) (standardized β=‐0.26, 95%CI [‐0.46,‐0.06], p = .013).

   “Higher tau PET uptake was associated with lower plasma Aβ42 (standardized β=‐0.26, 95%CI [‐0.46,‐0.06], p = .013)”

   Humansadjusted for age, sex, and cognitive groupplasman = 122

   Correlation Between Plasma Biomarkers Identified in Normal, SCD, and MCI subjects, with PET Amyloid and Tau Neuroimaging

   AAIC 2025 abstract·Jan 9, 2026

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1. Basal forebrain functional connectivity predicts tau PET uptake in humans (cognitively normal) (d=0.49).

   “effects were greater for the ERC seed compared to BF (proportion of suprathreshold voxels: ERC d=0.85; BF d=0.49).”

   Humanscognitively normal

   Basal forebrain and entorhinal cortex functional connectivity predicts regional tau burden in cognitively normal older adults

   AAIC 2025 abstract·Dec 23, 2025

1. Entorhinal cortex functional connectivity predicts tau PET uptake in humans (cognitively normal) (d=0.85).

   “Tau‐PET uptake was significantly greater in both the ERC and BF FC network compared to outside the network”

   Humanscognitively normal

   Basal forebrain and entorhinal cortex functional connectivity predicts regional tau burden in cognitively normal older adults

   AAIC 2025 abstract·Dec 23, 2025

1. P-TAU205 is associated with tau PET uptake in humans (Aβ-positive individuals) (R2=0.29).

   “In Aβ-positive individuals, cross-sectional p-tau205 correlated with Aβ-PET (R2=0.26), tau-PET (R2=0.29), cortical atrophy (R2=0.14) and cognition (MMSE, R2=0.14).”

   HumansAβ-positive individualscerebrospinal fluid

   P-TAU205 IS A BIOMARKER LINKED TO TAU-PET ABNORMALITY: A CROSS-SECTIONAL AND LONGITUDINAL STUDY

   medRxiv : the preprint server for health sciences·Oct 22, 2025Preprint

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