Tau neurofibrillary tangle density

Age is associated with tau neurofibrillary tangle density in humans (β = -0.38, p < 0.001).

“Among Braak‐V/VI autopsy cases ( n = 599), older age (β=‐0.38, p <0.001), but not male sex (β=‐0.05, p = 0.23), was associated with lower tangle density”

Humansamong Braak-V/VI autopsy casesn = 599

Lower Antemortem [ ¹⁸ F]flortaucipir PET retention in Males and Older Individuals is Explained by Lower Postmortem Tau Tangle Density

AAIC 2025 abstract·8 Jan 2026