TaM clock

1. TaM clock has no effect on mortality in humans.

   “predictions generated by either targeted clock were not significantly associated with mortality and there was no clear relationship with frailty or age-related clinical parameters in this larger cohort.”

   Humansin ActiFE cohortn = 446

   Exploring a targeted epigenetic clock based on mortality-associated CpGs as a potential biomarker for frailty

   Clinical epigenetics·7 Jul 2026

1. TaM clock is associated with frailty in humans.

   “in this subset the TaM clock revealed significant association between the delta age and the frailty status based on a 32-item frailty index.”

   Humansin subset of 20 frail and 20 non-frail individuals

   Exploring a targeted epigenetic clock based on mortality-associated CpGs as a potential biomarker for frailty

   Clinical epigenetics·7 Jul 2026

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