T-cell receptor repertoire diversity

1. INTERLEUKIN-21 increases T-cell receptor repertoire diversity in mice.

   “Enhanced production of naïve T cells improved the T-cell receptor (TCR) repertoire diversity”

   Animalsenhanced naïve T-cell production following rIL-21 treatmentT cell

   Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis

   Aging cell·Jan 13, 2016

More on INTERLEUKIN-21

1. T-cell receptor repertoire diversity predicts immune collapse in silico.

   “making T-cell receptor diversity ($\Gamma_{immune}$) the definitive geometric precursor to immune collapse.”

   In silicoTheoretical prediction of the SRSM framework when central thymic input fades; not empirically validated in the abstractperipheral immune system

   The Architecture of Self-Referential Failure: A Unified Theory of SRSM Systems. Bayesian Self-Reference · Immune Ageing as SRSM

   Zenodo (CERN European Organization for Nuclear Research)·May 27, 2026Preprint