Aging Cell
MTR4 protein restores youthful traits in human blood vessel cells
In laboratory experiments, depleting the protein triggered premature senescence, a state in which cells stop dividing, in human umbilical vein cells.In laboratory experiments, depleting the protein triggered premature senescence, a state in which cells stop dividing, in human umbilical vein cells.
Experiments in serially passaged, senescent HUVECs, against vector-control senescent HUVECsMechanisms
Limit: Youthfulness was inferred from senescence markers rather than direct tests of restored cell function