Synaptic protein content distribution shapes

Age is associated with synaptic protein content distribution shapes in mice.

“Regions which at three months of age have thinner tails largely conserve their distribution shapes later in life, whereas heavy tails in other regions strikingly grow ever more so.”

AnimalsRegional differences according to distribution tail shape at three monthsbrain

Shapes of synaptic protein distributions distinguish brain architectures

bioRxiv (Cold Spring Harbor Laboratory)·22 Dec 2025Preprint

Synaptic protein content distribution shapes are associated with regional brain architecture in mice (three main clusters).

“We identified a hierarchical organization of regions along the anterior–posterior axis, with three main clusters of divergent synaptic population shapes.”

Animalsbrain

Shapes of synaptic protein distributions distinguish brain architectures

bioRxiv (Cold Spring Harbor Laboratory)·22 Dec 2025Preprint