Synaptic autoantigen-specific T helper cell frequency

1. Synaptic autoantigen-specific T helper cell frequency has no effect on cognitive impairment in humans.

   “This first direct ex vivo quantitative and qualitative analysis of circulating T cells autoreactive to three synaptic autoantigens in dementia shows no correlation with cognitive impairment.”

   Humansdementia

   Frequency of synaptic antigen-specific CD4⁺ T cells in dementia is age-dependent but not correlated with cognitive impairment

   Immunity & ageing : I & A·19 Jun 2025

1. Dementia has no effect on synaptic autoantigen-specific T helper cell frequency in humans.

   “synaptic autoantigen-specific TH cells occurred in all cohorts and were similarly frequent in patients with dementia and sex- and age-matched controls.”

   Humansdementia versus sex- and age-matched controlscirculating T helper cell

   Frequency of synaptic antigen-specific CD4⁺ T cells in dementia is age-dependent but not correlated with cognitive impairment

   Immunity & ageing : I & A·19 Jun 2025

More on Dementia

1. Age is associated with synaptic autoantigen-specific T helper cell frequency in humans.

   “However, they were significantly reduced compared to young healthy subjects, indicating strong age-related effects ('immune senescence').”

   Humansolder participants compared with young healthy subjectscirculating T helper cell

   Frequency of synaptic antigen-specific CD4⁺ T cells in dementia is age-dependent but not correlated with cognitive impairment

   Immunity & ageing : I & A·19 Jun 2025