IFNγ expression in synaptic autoantigen-specific T helper cells

Age is associated with IFNγ expression in synaptic autoantigen-specific T helper cells in humans.

“synaptic autoantigen-specific TH cell responses were strongly driven by IFNγ-producing T cells, expression of which markedly decreased with age.”

Humanscirculating T helper cell

Frequency of synaptic antigen-specific CD4⁺ T cells in dementia is age-dependent but not correlated with cognitive impairment

Immunity & ageing : I & A·19 Jun 2025