Striatal dopamine transporter binding

1. Striatal dopamine transporter binding was not clearly linked with pain severity in humans (cross-sectional analysis).

   “Cross-sectional striatal DAT binding was not associated with symptom severity.”

   Humanscross-sectional analysisstriatumn = 244

   People with a dream-enactment disorder reported greater pain

   Parkinsonism & related disorders·Nov 1, 2026

1. Striatal dopamine transporter binding is linked with association between age and parkinsonian motor signs in humans (fully adjusted mediation model) (30% reduction; indirect effect 0.027 (95% CI 0.0007–0.074)).

   “DAT significantly reduced the age-UPDRSm association by 30%”

   Humansfully adjusted mediation modelstriatumn = 87

   Influence of Striatal Dopamine, Cerebral Small Vessel Disease, and Other Risk Factors on Age-Related Parkinsonian Motor Signs

   The journals of gerontology. Series A, Biological sciences and medical sciences·Aug 20, 2019

1. Parkinson's disease is linked with lower striatal dopamine transporter binding in humans (longitudinal follow-up) (4.2 % annually).

   “striatal DAT binding declined in PD (4.2 % annually, p < 0.001)”

   Humanslongitudinal follow-up

   Hand muscle strength in Parkinson's disease: A Sarcopenic epiphenomenon or a meaningful biomarker?

   Parkinsonism & related disorders·Sep 3, 2025

More on Parkinson's disease

1. follow-up time is associated with striatal dopamine transporter binding in humans (asymptomatic LRRK2 G2019S mutation carriers) (Mean annual decline of 3.5%).

   “There was a significant decline of DaT binding over time, with a mean annual rate of 3.5%”

   Humansasymptomatic LRRK2 G2019S mutation carriersstriatum8 years

   Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8 years' follow-up

   European journal of neurology·Aug 19, 2021

1. Parkinson's disease conversion is associated with striatal dopamine transporter binding in humans (asymptomatic LRRK2 G2019S mutation carriers; converters compared with non-converters).

   “PD-converters had lower striatal DaT binding at baseline than non-converters.”

   Humansasymptomatic LRRK2 G2019S mutation carriers; converters compared with non-convertersstriatumbaseline

   Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8 years' follow-up

   European journal of neurology·Aug 19, 2021

1. Striatal dopamine transporter binding is associated with coding digit symbol performance in humans (all striatal regions except left caudate; path analysis models not significant).

   “Multiple regression analyses revealed that the coding digit symbol correlated with all striatal regions except for the left caudate (P < 0.04).”

   Humansall striatal regions except left caudate; path analysis models not significantstriatumn = 30

   The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging

   Frontiers in aging neuroscience·Feb 28, 2020

1. Striatal dopamine transporter binding is associated with cognitive function in humans (age-adjusted DAT binding).

   “Full intelligence quotient (IQ), verbal IQ, verbal comprehension were all positively correlated with age-adjusted striatal DAT binding (P < 0.01).”

   Humansage-adjusted DAT bindingstriatumn = 30

   The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging

   Frontiers in aging neuroscience·Feb 28, 2020

1. Striatal dopamine transporter binding is associated with parkinsonian motor signs in humans (lower DAT binding associated with worse UPDRSm; sex-adjusted model).

   “Older age, lower DAT, higher WMH, and worse risk factors significantly predicted worse UPDRSm (sex-adjusted p < .04 for all).”

   Humanslower DAT binding associated with worse UPDRSm; sex-adjusted modelstriatumn = 87

   Influence of Striatal Dopamine, Cerebral Small Vessel Disease, and Other Risk Factors on Age-Related Parkinsonian Motor Signs

   The journals of gerontology. Series A, Biological sciences and medical sciences·Aug 20, 2019