Steady-state proteotoxic load

DNA replication asymmetry increases steady-state proteotoxic load in silico (Approximately 1–3% increase).

“Across homeostatic and near-failure regimes, replication asymmetry modestly increases steady-state proteotoxic load (approximately 1– 3%) and leads to modestly earlier collapse.”

In silicoHomeostatic and near-failure regimes

DNA Replication Asymmetry and Proteostasis Collapse Dynamics

bioRxiv (Cold Spring Harbor Laboratory)·10 Dec 2025Preprint