Somatic single nucleotide variant accumulation rate

Oligodendrocyte is associated with somatic single nucleotide variant accumulation rate in humans (69% faster; 27/year versus 16/year).

“oligodendrocytes accumulate sSNVs 69% faster than neurons (27/year versus 16/year)”

Humanscompared with neurons in neurotypical individualsoligodendrocyte

Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain

bioRxiv : the preprint server for biology·Jan 14, 2023Preprint