Somatic mutations in open, transcriptionally active chromatin

Neuron is associated with somatic mutations in open, transcriptionally active chromatin in humans.

“In contrast, neuronal mutations are enriched in open, transcriptionally active chromatin.”

Humansneurotypical individualsbrain

Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain

bioRxiv : the preprint server for biology·Jan 14, 2023Preprint