Somatic mutations in inactive genomic regions

Oligodendrocyte is associated with somatic mutations in inactive genomic regions in humans.

“oligodendrocyte mutations are enriched in inactive genomic regions and are distributed similarly to mutations in brain cancers.”

Humansneurotypical individualsbrain

Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain

bioRxiv : the preprint server for biology·Jan 14, 2023Preprint