Somatic mutation accumulation rate

1. Osteoarthritis decreases somatic mutation accumulation rate in humans.

   “Surprisingly, the age-related accumulation rate in OA chondrocytes is lower than that in non-OA control chondrocytes.”

   Humansosteoarthritiscartilage of hip femoral headsn = 17

   Single-cell analysis of the somatic mutational landscape in human chondrocytes during aging and in osteoarthritis

   Nature aging·17 Nov 2025

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