Somatic mutation accumulation
1 paper1 finding
- Animals1
Upstream
1NPAS4-NuA4 complex
downin animals1
1 study
NPAS4-NuA4 complex
downin animals1
NPAS4-NuA4 complex protects against somatic mutation accumulation.
“Gene regulatory elements bound by NPAS4-NuA4 are partially protected against age-dependent accumulation of somatic mutations.”
Animalsgene regulatory elements bound by NPAS4-NuA4brain
A NPAS4-NuA4 complex couples synaptic activity to DNA repair
Nature15 Feb 2023
Latest
3 in 12 monthsCell
Caloric restriction modulates genome-wide somatic mutation in mice
Experiments in miceDietary restriction
Ageing Research Reviews
Somatic mutations in human ontogenesis and their impact on health
ReviewMechanisms
AAIC 2025 Abstract
Neurons accumulate disease‐specific somatic deletions across tau pathological states in Alzheimer’s disease
Study in peopleMechanisms
GSA 2024 Abstract
SINGLE-CELL ANALYSIS OF SOMATIC MUTATIONS IN HUMAN LUNG REVEALS ASSOCIATION WITH TRANSCRIPTIONAL CHANGES IN AGING
Study in peopleMechanisms