SLICC-FI

1. SLICC-FI predicts days of hospitalisations in humans (IRR: 2.018 (95% CI: 1.715 to 2.375)).

   “and IRR: 2.018 (95% CI: 1.715 to 2.375), respectively).”

   Humansper 0.05 increase, adjusted for possible confounders3 yearsn = 295

   Systemic Lupus International Collaborating Clinics-Frailty Index predicts hospitalisations in the Almenara Lupus Cohort

   Lupus science & medicine·Jul 13, 2025

1. SLICC-FI predicts hospitalizations in humans (IRR: 1.671 (95% CI: 1.385 to 2.016)).

   “The SLICC-FI predicted a higher number and days of hospitalisations (incidence rate ratio (IRR): 1.671 (95% CI: 1.385 to 2.016)”

   Humansper 0.05 increase, adjusted for possible confounders3 yearsn = 295

   Systemic Lupus International Collaborating Clinics-Frailty Index predicts hospitalisations in the Almenara Lupus Cohort

   Lupus science & medicine·Jul 13, 2025

1. SLICC-FI is associated with atherosclerotic plaque in humans (OR 1.34, p=0.03 per 0.05 point increase).

   “SLICC-FI (OR 1.34, p=0.03 per 0.05 point increase) remained significant in multivariate analysis”

   Humansafter adjustment for traditional and disease-related CVR factors

   Frailty is independently associated with subclinical cardiovascular disease in patients with systemic lupus erythematosus

   RMD open·Sep 23, 2024

1. SLICC-FI is associated with bone mineral density in humans.

   “We also found an association between the SLICC-FI and low BMD.”

   Humanssystemic lupus erythematosusfemales

   SLICC-Frailty Index and Its Association with Low Bone Mineral Density and Vertebral Fractures in Women with Systemic Lupus Erythematosus

   Calcified tissue international·Jul 23, 2023

1. SLICC-FI is associated with vertebral fracture in humans (OR 5.76, 95% CI 2.53-13.12; P < 0.001).

   “Both univariate and multivariate models showed associations between frailty (defined as SLICC-FI > 0.21) and prevalent VF in the entire population (OR 5.76, 95% CI 2.53-13.12; P < 0.001)”

   Humanssystemic lupus erythematosusfemales

   SLICC-Frailty Index and Its Association with Low Bone Mineral Density and Vertebral Fractures in Women with Systemic Lupus Erythematosus

   Calcified tissue international·Jul 23, 2023

More on Vertebral fracture

1. SLICC-FI predicts organ damage accrual in humans (OR 1.28, 95% CI 1.01-1.63).

   “each 0.05-unit increase in the baseline SLICC-FI score was associated with 28% higher odds of subsequent damage accrual (odds ratio 1.28, 95% confidence interval 1.01-1.63)”

   Humanslongstanding SLE5-year follow-upfemalesn = 149

   Association of the Systemic Lupus International Collaborating Clinics Frailty Index and Damage Accrual in Longstanding Systemic Lupus Erythematosus

   Arthritis care & research·Oct 1, 2021

1. SLICC-FI predicts organ damage in humans (IRR 1.18 (95% CI 1.07, 1.29) per 0.05 increase).

   “Higher baseline SLICC-FI values (per 0.05 increase) were associated with increased damage accrual over time [incidence rate ratio 1.18 (95% CI 1.07, 1.29)]”

   Humansadjusted for potential confoundersper 0.05 increasen = 183

   External validation of the Systemic Lupus International Collaborating Clinics Frailty Index as a predictor of adverse health outcomes in systemic lupus erythematosus

   Rheumatology (Oxford, England)·Aug 20, 2021

1. SLICC-FI predicts mortality in humans (HR 1.31 (95% CI 1.01, 1.70) per 0.05 increase).

   “Higher baseline SLICC-FI values (per 0.05 increase) were associated with an increased mortality risk [hazard ratio 1.31 (95% CI 1.01, 1.70)]”

   Humansadjusted for age, sex, education, SLE medication use, disease duration, smoking status and baseline SDIper 0.05 increasen = 183

   External validation of the Systemic Lupus International Collaborating Clinics Frailty Index as a predictor of adverse health outcomes in systemic lupus erythematosus

   Rheumatology (Oxford, England)·Aug 20, 2021