Shared transcriptomic axis of senescence progression

1. Cellular senescence is associated with shared transcriptomic axis of senescence progression in human cells.

   “Across all four senescent inducers, global transcriptomic variation aligned along a shared axis of senescence progression, consistent with established machine learning-based senescence classifiers.”

   CellsSenescence induced by replicative exhaustion, bleomycin, hydrogen peroxide, or ionizing radiationhuman primary lung fibroblasts (IMR-90)

   A transcriptomic analysis reveals shared and inducer-specific expression patterns of cellular senescence

   bioRxiv : the preprint server for biology·23 Apr 2026Preprint

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