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Senescore

Biomarker

1 paper3 findings

  • Humans1

Effects

1

Senescence-associated secretory phenotype (SASP)

upin humans1

1 study

  1. Senescore increases senescence-associated secretory phenotype (SASP) in humans.

    “patients categorized within higher Senescore group were predisposed to the basal subtype, showcased augmented immune infiltration, harbored elevated driver gene mutations, and exhibited increased senescence-associated secretory phenotype (SASP) factors expression”

    Humanshigher Senescore group

    Senescence-specific molecular subtypes stratify the hallmarks of the tumor microenvironment and guide precision medicine in bladder cancer

    BMC cancer19 Feb 2025

More on Senescence-associated secretory phenotype (SASP)

Associations

2

Mortality

upin humans1

1 study

  1. Senescore is associated with mortality in humans.

    “Despite poorer prognoses, these patients revealed greater responsiveness to immunotherapy and neoadjuvant chemotherapy.”

    Humanshigher Senescore group

    Senescence-specific molecular subtypes stratify the hallmarks of the tumor microenvironment and guide precision medicine in bladder cancer

    BMC cancer19 Feb 2025

Immunotherapy response

upin humans1

1 study

  1. Senescore predicts immunotherapy response in humans.

    “Despite poorer prognoses, these patients revealed greater responsiveness to immunotherapy and neoadjuvant chemotherapy.”

    Humanshigher Senescore group

    Senescence-specific molecular subtypes stratify the hallmarks of the tumor microenvironment and guide precision medicine in bladder cancer

    BMC cancer19 Feb 2025

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