Senescent features

1 paper studies it111 more mention it

Cells1

Latest

21 papers in 12 months

Nature MetabolismOct 15

Linked metabolic disruptions halt division in human cells

An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the…An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the lab.

Human cell studyInterventions

Paper

bioRxivSep 29

T cell KRAS upregulation is linked to premature coronary disease

Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery disease.Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery disease.

Preprint: case-control study in peopleKRAS

Paper

bioRxivSep 29

A distinct p21-driven macrophage senotype accumulates during aging and liver disease

Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.

Preprint: experiments in miceMechanisms

Paper

Research SquareSep 9