Senescent beta cells

2 papers1 finding

Animals1
Cells1

Interventions

1

BCL-2 inhibitors

downin mice1

1 study

BCL-2 inhibitors decrease senescent beta cells in mice.
“treatment of NOD mice with Bcl-2 inhibitors selectively eliminated these cells”
Animalsin NOD mice
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
Cell metabolism21 Feb 2019

More on BCL-2 inhibitors

Funding

1 grant since 2023

National Institute of Diabetes and Digestive and Kidney DiseasesUS$2.1m

The role of senescent beta cells in T1D and T2D
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of PennsylvaniaUS$680.5k2022–2027

Latest

ADA Scientific Sessions 2025 Abstract13 Jun

Targeting β-Cell Senescence and Secondary Senescence—Therapeutic Potential of JAK Inhibitors in Diabetes

Experiments in human cellsCellular senescence

Cell Metabolism21 Feb

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

Experiments in miceType 1 diabetes