Senescence-related scoring model

1. Senescence-related scoring model increases regulatory T cell infiltration in silico.

   “immunosuppressive tumor microenvironment (TME) characterized by elevated regulatory T cell (Treg) infiltration”

   In silicohigh SRSM ccRCC patients

   Machine learning-derived cellular senescence index for predicting prognosis and drug sensitivity in patients with renal cell carcinoma

   Frontiers in immunology·16 Dec 2025

More on Regulatory T cell infiltration

1. Senescence-related scoring model increases oxidative phosphorylation in silico.

   “Patients with high SRSM exhibited significantly poorer survival (P < 0.001), enhanced oxidative phosphorylation”

   In silicohigh SRSM ccRCC patients

   Machine learning-derived cellular senescence index for predicting prognosis and drug sensitivity in patients with renal cell carcinoma

   Frontiers in immunology·16 Dec 2025

More on Oxidative phosphorylation

1. Senescence-related scoring model decreases survival in silico (P < 0.001).

   “Patients with high SRSM exhibited significantly poorer survival (P < 0.001)”

   In silicoccRCC patients

   Machine learning-derived cellular senescence index for predicting prognosis and drug sensitivity in patients with renal cell carcinoma

   Frontiers in immunology·16 Dec 2025