Senescence-associated distention of satellite DNA

1. Histone deacetylase inhibitors increase senescence-associated distention of satellite DNA in mouse cells.

   “Hdac inhibitors also increased the number of SADS in Runx2 + LD+ and Runx2 + LD- WT BMSCs.”

   Cellswild-type cells, both lipid-droplet-positive and lipid-droplet-negativeRunx2-positive bone marrow stromal cells

   Hdac3-deficiency increases senescence-associated distention of satellite DNA and telomere-associated foci in osteoprogenitor cells

   Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·Jun 6, 2024

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1. HDAC3 decreases senescence-associated distention of satellite DNA in mouse cells.

   “Runx2+ BMSCs from Hdac3 CKOOsx mice also contained more SADS and TAFs per nuclei than Runx2+ cells from age-matched control mice in vitro.”

   Cellsshown by conditional Hdac3 deletion compared with age-matched controlsRunx2-positive bone marrow stromal cells

   Hdac3-deficiency increases senescence-associated distention of satellite DNA and telomere-associated foci in osteoprogenitor cells

   Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·Jun 6, 2024

More on HDAC3