ROS-induced Akt activation

1. PTEN is required for ROS-induced Akt activation in flies.

   “We identify cysteine 79 as an essential residue for redox regulation of PTEN, demonstrating that a ROS-insensitive PTEN mutant uncouples Akt activation from oxidative stress.”

   Model organismsRedox regulation of Pten; tested using a ROS-insensitive Pten mutant

   Oxidative inhibition of PTEN links ROS signaling to regeneration and homeostasis

   bioRxiv (Cold Spring Harbor Laboratory)·3 Aug 2026Preprint

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