Regression of liver-unique methylation toward the pan-tissue average

Normal aging is associated with regression of liver-unique methylation toward the pan-tissue average in silico.

“In addition, we demonstrate that this regression also occurs in a majority of these sites during normal aging.”

In siliconormal agingliver

Reversible and causal epigenetic information loss in liver aging and disease

PNAS nexus·10 Apr 2026

Liver disease progression is associated with regression of liver-unique methylation toward the pan-tissue average in silico.

“Upon disease progression, these sites overwhelmingly regress toward the pan-tissue average.”

In silicodisease progressionliver

Reversible and causal epigenetic information loss in liver aging and disease

PNAS nexus·10 Apr 2026