PSA-NCAM

1. Amyloid-beta decreases PSA-NCAM in human cells (up to 60%).

   “Analysis of protein and mRNA expression levels following Aβ treatment in IMR‐32 cells revealed significant downregulation (up to 60%) in ST8Sia4, PSA‐NCAM, and UDP‐E across all concentrations.”

   Cellsin IMR-32 neuroblastoma cellsneuroblastoma cells

   Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA‐NCAM in brain aging and Alzheimer's disease

   AAIC 2025 abstract·23 Dec 2025

More on Amyloid-beta

1. Alzheimer's disease decreases PSA-NCAM in mice (by 43–58%).

   “PSA‐NCAM expression was downregulated in AD mice (by 43–58%, n≥4), particularly in the hippocampus and prefrontal cortex, while increasing with normal aging (up to 2‐fold, n≥4).”

   Animalsin AD miceprefrontal cortex and hippocampusn = 4

   Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA‐NCAM in brain aging and Alzheimer's disease

   AAIC 2025 abstract·23 Dec 2025

More on Alzheimer's disease