Extrasynaptic GluN2B

1. Alzheimer's disease increases extrasynaptic GluN2B in mice (2–3-fold).

   “ES‐GluN2B levels were significantly elevated in AD mice (2–3‐fold, n≥4), but unchanged in WT mice.”

   Animalsin AD micebrainn = 4

   Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA‐NCAM in brain aging and Alzheimer's disease

   AAIC 2025 abstract·23 Dec 2025

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