Proteomic frailty index

1. Proteomic frailty index predicts mortality in humans (HR 1.13 (95% CI 1.12–1.14)).

   “The pFI were also associated with mortality (LonGenity: HR [95% CI] = 1.12 [1.07-1.18]; ARIC: HR [95% CI] = 1.13 [1.12–1.14]; BLSA: HR [95% CI] = 1.11 [1.05–1.17]).”

   Humansin ARIC cohortplasma

   A Frailty-Based Plasma Proteomic Signature Capturing Overall Health and Well-Being in Older Adults · GSA 2025 abstract · 31 Dec 2025

1. Proteomic frailty index raises the risk of dementia in humans (HR 1.07 (95% CI 1.05-1.09)).

   “incident dementia (HR [95% CI] = 1.07 [1.05-1.09], follow-up: 7.22 [1.82] years).”

   Humansin ARIC cohortplasma7.22 years

   A Frailty-Based Plasma Proteomic Signature Capturing Overall Health and Well-Being in Older Adults · GSA 2025 abstract · 31 Dec 2025

Dementia →

1. Proteomic frailty index is associated with frailty in humans (r = 0.61).

   “Atherosclerosis Risk in Communities (ARIC) study (N = 5195, r = 0.61, p < 0.001)”

   Humansin ARIC cohortplasman = 5,195

   A Frailty-Based Plasma Proteomic Signature Capturing Overall Health and Well-Being in Older Adults · GSA 2025 abstract · 31 Dec 2025